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D-Alanine Metabolism in S. pyogenes SSI-1

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Group-A Streptococcus pyogenes remains an important human pathogen responsible for a variety of suppurative infections, including pharyngitis, scarlet fever, impetigo, and cellulitis and for nonsuppurative sequelae, such as acute rheumatic fever, acute glomerulonephritis, and reactive arthritis (Ref.1). S. pyogenes strains are grouped into two classes on the basis of post infectious sequelae associated with each strain, Class-I is responsible for rheumatic fever and Class-II is responsible for acute glomerulonephritis. S. pyogenes strain SSI-1 (Serotype M3) is among the most prevalent in terms of involvement in severe invasive infections (Ref.2 & 3).

As is the case in other Gram-positive bacteria, the cell wall of S. pyogenes is associated with an array of proteins which can share common structural features (Ref.4). The cell [...]


1.Pathogenesis of group A streptococcal infections.
Cunningham MW.
Clin. Microbiol. Rev. 2000 Jul; 13(3):470-511.
2.Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients.
Terao Y, Kawabata S, Nakata M, Nakagawa I, Hamada S.
J. Biol. Chem. 2002 Dec 6; 277(49):47428-35.
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