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D-Alanine Metabolism in S. pyogenes MGAS10394

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Group-A Streptococcus pyogenes remains an important human pathogen responsible for a variety of suppurative infections, including pharyngitis, scarlet fever, impetigo, and cellulitis and for nonsuppurative sequelae, such as acute rheumatic fever, acute glomerulonephritis, and reactive arthritis (Ref.1). S. pyogenes strains are grouped into two classes on the basis of post infectious sequelae associated with each strain, Class-I is responsible for rheumatic fever and Class-II is responsible for acute glomerulonephritis. S. pyogenes strain MGAS10394 is the first Streptococcus M6 genome to be sequenced and is the largest Group-A Streptococcus genome sequenced to date (Ref.2 & 3).

As is the case in other Gram-positive bacteria, the cell wall of S. pyogenes is associated with an array of proteins which can share common structural [...]


1.Pathogenesis of group A streptococcal infections.
Cunningham MW.
Clin Microbiol Rev. 2000 Jul; 13(3):470-511. Review.
2.Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain.
Banks DJ, Porcella SF, Barbian KD, Beres SB, Philips LE, Voyich JM, DeLeo FR, Martin JM, Somerville GA, Musser JM.
J Infect Dis. 2004 Aug 15; 190(4):727-38. Epub 2004 Jul 20.
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