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D-Alanine Metabolism in S. pyogenes MGAS8232

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Group-A Streptococcus pyogenes remains an important human pathogen responsible for a variety of suppurative infections, including pharyngitis, scarlet fever, impetigo, and cellulitis and for nonsuppurative sequelae, such as acute rheumatic fever, acute Glomerulonephritis, and reactive arthritis (Ref.1). S. pyogenes strains are grouped into two classes on the basis of post infectious sequelae associated with each strain, Class-I is responsible for rheumatic fever and Class-II is responsible for acute glomerulonephritis. S. pyogenes strain MGAS8232 (Serotype M18) was isolated from a patient with acute rheumatic fever. The Serotype M18 is among the most prevalent in terms of involvement in severe invasive infections (Ref.2, 3 & 4).

As is the case in other Gram-positive bacteria, the cell wall of S. pyogenes is associated with [...]


1.Pathogenesis of group A streptococcal infections.
Cunningham MW.
Clin. Microbiol. Rev. 2000 Jul; 13(3):470-511.
2.Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence.
Beres SB, Sylva GL, Barbian KD, Lei B, Hoff JS, Mammarella ND, Liu MY, Smoot JC, Porcella SF, Parkins LD, Campbell DS, Smith TM, McCormick JK, Leung DY, Schlievert PM, Musser JM.
Proc. Natl. Acad. Sci. U S A. 2002 Jul 23; 99(15):10078-83.
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