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D-Alanine Metabolism in S. pyogenes SF370

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The Group-A Streptococcus (Streptococcus pyogenes) remains an important human pathogen, associated with a range of superficial skin and throat infections as well as a variety of more serious invasive infections and autoimmune sequelae such as acute rheumatic fever and post-streptococcal glomerulonephritis (Ref.1). S. pyogenes strains are grouped into two classes on the basis of post infectious sequelae associated with each strain, Class-I is responsible for rheumatic fever and Class-II is responsible for acute glomerulonephritis. S. pyogenes strain SF370 (Serotype M1) was originally isolated from a patient with a wound infection. The Serotype M1 is among the most prevalent in terms of involvement in severe invasive infections (Ref.2 & 3).

As is the case in other Gram-positive bacteria, the cell wall of [...]


1.Pathogenesis of group A streptococcal infections.
Cunningham MW.
Clin Microbiol Rev. 2000 Jul; 13(3):470-511.
2.Genome analysis of an inducible prophage and prophage remnants integrated in the Streptococcus pyogenes strain SF370.
Canchaya C, Desiere F, McShan WM, Ferretti JJ, Parkhill J, Brussow H.
Virology. 2002 Oct 25; 302(2):245-58.
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