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Description |
The Group-A Streptococcus (Streptococcus pyogenes) remains an important human pathogen, associated with a range of superficial skin and throat infections as well as a variety of more serious invasive infections and autoimmune sequelae such as acute rheumatic fever and post-streptococcal glomerulonephritis (Ref.1). S. pyogenes strains are grouped into two classes on the basis of post infectious sequelae associated with each strain, Class-I is responsible for rheumatic fever and Class-II is responsible for acute glomerulonephritis. S. pyogenes strain SF370 (Serotype M1) was originally isolated from a patient with a wound infection. The Serotype M1 is among the most prevalent in terms of involvement in severe invasive infections (Ref.2 & 3).
As is the case in other Gram-positive bacteria, the cell wall of [...] |
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References:
1. Pathogenesis of group A streptococcal infections.Cunningham MW.Clin Microbiol Rev. 2000 Jul; 13(3):470-511.2. Genome analysis of an inducible prophage and prophage remnants integrated in the Streptococcus pyogenes strain SF370.Canchaya C, Desiere F, McShan WM, Ferretti JJ, Parkhill J, Brussow H.Virology. 2002 Oct 25; 302(2):245-58.
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