About Us
Contact Us
Login to Protein Lounge!

D-Alanine Metabolism in S. thermophilum

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Symbiobacterium thermophilum is a symbiotic Gram-negative and tryptophanase-positive thermophile. It is an uncultivable bacterium isolated from compost that depends on microbial commensalism. It does not grow by itself under standard culture conditions; however, when cocultured with Bacillus sp., it propagates. S.thermophilum proliferates under both aerobic and anaerobic conditions (Ref.1, 2 & 3).

The cell wall of this Gram-negative bacterium constitutes a multifaceted fabric that is essential for survival, shape, and integrity. Macromolecular assemblies of cross-linked peptidoglycan, polyanionic TAs (Teichoic Acids), and surface proteins function within this envelope. A key step in peptidoglycan layer assembly and deposition in the cell wall of S. thermophilum is the subsequent enzymic cross-linking of one peptidoglycan strand to an adjacent one in cell wall growth. D-Alanine [...]


1.A regulatory system hitherto found only in gram-positive bacteria in a gram-negative bacterium that grows only in co-culture with a Bacillus strain.
Grundy FJ, Henkin TM.
Mol Microbiol. 1999 Aug; 33(3):667-8.
2.Symbiobacterium thermophilum gen. nov., sp. nov., a symbiotic thermophile that depends on co-culture with a Bacillus strain for growth.
Ohno M, Shiratori H, Park MJ, Saitoh Y, Kumon Y, Yamashita N, Hirata A, Nishida H, Ueda K, Beppu T.
Int J Syst Evol Microbiol. 2000 Sep; 50 Pt 5:1829-32.
You can get all the details on this pathway through subscription