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DHA Signaling

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The cell membranes do not simply serve as barriers to separate the inside of the cell from the outside or to delineate different intracellular compartments. These membranes also serve as a platform for cell signaling by allowing specific sets of proteins to interact. Phospholipids are major structural constituents of the cell membranes. In the cell membranes of neurons, the two most prevalent Phospholipids include PC (Phosphatidylcholine) and PS (Phosphatidylserine). When cell membranes are stimulated by cell signaling activity, enzymes (called Phospholipases) free lipid messengers from these reservoirs. The lipid messengers then regulate and interact with other signaling cascades to contribute to the development, differentiation, function protection, and repair of the nervous system. Some of these messengers are derived from essential fatty acids [...]


1.Docosahexaenoic acid and neurologic development in animals.
Heinemann KM, Bauer JE.
J Am Vet Med Assoc. 2006 Mar 1;228(5):700-5, 655.
2.Role of docosahexaenoic acid in neuronal plasma membranes.
Glomset JA.
Sci STKE. 2006 Feb 7;2006(321):pe6.
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