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DNA Damage Induced 14-3-3Sigma Signaling

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DNA damage checkpoints are critical for preventing tumorigenesis and regulating the response of cells to genotoxic agents. When cells are exposed to DNA damaging agents, they respond by undergoing cell cycle arrest or programmed cell death. 14-3-3 proteins play particularly important roles in coordinating progression of cells through the cell cycle, regulating their response to DNA damage, and influencing life-death decisions following internal injury or external cytokine-mediated cues (Ref.1 and 2). 14-3-3 sigma (also called stratifin or SFN), a tumor suppressor, is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. Its increased expression causes resistance to anticancer agents and radiation that causes DNA damages (Ref.3).

The 14-3-3 sigma gene is induced [...]


1.14-3-3sigma and p21 synergize to determine DNA damage response following Chk2 inhibition.
Meng S, Arbit T, Veeriah S, Mellinghoff IK, Fang F, Vivanco I, Rohle D, Chan TA.
Cell Cycle. 2009 Jul 15;8(14):2238-46. Epub 2009 Jul 12.
2.14-3-3 proteins as signaling integration points for cell cycle control and apoptosis.
Gardino AK, Yaffe MB.
Semin Cell Dev Biol. 2011 Sep;22(7):688-95. doi: 10.1016/j.semcdb.2011.09.008. Epub 2011 Sep 14. Review.
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