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Description |
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The 14-3-3 proteins comprise a large family of highly conserved, small, acidic
polypeptides of 28¡V33 kDa that are found in all eukaryotic species and play
important roles in a wide range of cellular processes including signal
transduction, apoptosis, cell cycle progression, and checkpoint activation
(Ref.1). In humans, seven different genes encode the highly conserved 14-3-3
isotypes (Alpha, Beta, Gamma, Delta, Epsilon, Eta, Sigma, Tau, and Zeta, with
Alpha and Delta being phosphorylated forms of Beta and Zeta). The 14-3-3
proteins regulate numerous cellular signaling circuits that are implicated in
cancer development. They bind to protein ligands¡X following their
serine/threonine phosphorylation at a defined motif¡Xand regulate their
activities by a number of different mechanisms. These include inter- and
intracompartmental sequestration, activation/inactivation [...] |
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