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DR3 Signaling

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The TNFR (Tumor Necrosis Factor Receptor) superfamily comprises a growing family of type I membrane bound glycoproteins, which interact with the TNF family of soluble mediators and type II transmembrane proteins. At least 23 TNFR superfamily members and 17 known ligands have been identified in mammals. These receptors trigger pleiotropic responses, ranging from apoptosis and differentiation to proliferation, and have been implicated in immune regulation, host defense and lymphoid organ development. Members of the TNFR family are characterized by the presence of varying numbers (two to six) of cysteine-rich repeats in their cytoplasmic domains. Among these molecules, a novel subgroup has been defined, termed DR (Death Receptors), as one of their most prominent functions is to induce apoptosis. DR are [...]


1.Programmed cell death.
Gottlieb RA.
Drug News Perspect. 2000 Oct;13(8):471-6.
2.Death receptor signaling giving life to ectodermal organs.
Thesleff I, Mikkola ML.
Sci STKE. 2002 May 7;2002(131):PE22.
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