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DREAM Repression and Dynorphin Expression

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The experience of pain in response to noxious stimuli serves a crucial biological purpose: it alerts a living organism to environmental dangers, inducing behavioral responses that protect the organism from further damage. In contrast, chronic pain arising from disease states and/or pathological functioning of the nervous system offers no advantage and may be debilitating to those afflicted. Control and treatment of chronic pain remain major clinical challenges. The calcium-sensing protein DREAM (Downstream Regulatory Element Antagonistic Modulator) is a putative transcriptional repressor involved in modulating pain (Ref.1).

DREAM is constitutively expressed in certain neurons and transcriptional activity of the repressor DREAM depends on its high affinity binding to a DRE (Downstream Response Element) site in target genes, which is important in regulating [...]


1.DREAM is a critical transcriptional repressor for pain modulation.
Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, Salter MW, Penninger JM.
Cell. 2002 Jan 11; 108(1):31-43.
2.DREAM is a Ca2+-regulated transcriptional repressor.
Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR.
Nature. 1999 Mar 4; 398(6722):80-4.
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