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Description |
The experience of pain in response to noxious stimuli serves a crucial biological purpose: it alerts a living organism to environmental dangers, inducing behavioral responses that protect the organism from further damage. In contrast, chronic pain arising from disease states and/or pathological functioning of the nervous system offers no advantage and may be debilitating to those afflicted. Control and treatment of chronic pain remain major clinical challenges. The calcium-sensing protein DREAM (Downstream Regulatory Element Antagonistic Modulator) is a putative transcriptional repressor involved in modulating pain (Ref.1).
DREAM is constitutively expressed in certain neurons and transcriptional activity of the repressor DREAM depends on its high affinity binding to a DRE (Downstream Response Element) site in target genes, which is important in regulating [...] |
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References:
1. DREAM is a critical transcriptional repressor for pain modulation.Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, Salter MW, Penninger JM.Cell. 2002 Jan 11; 108(1):31-43.2. DREAM is a Ca2+-regulated transcriptional repressor.Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR.Nature. 1999 Mar 4; 398(6722):80-4.
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