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Dopamine-DARPP32 Feedback onto cAMP Pathway

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One of the ultimate frontiers for mankind is the elucidation of the function of the mind. Dopaminergic and Glutamergic are two primary neurotransmitter systems in the brain, which are crucially important for the control of the body musculature and the Dopamine-induced signaling pathways. Dopamine, a derivative of the amino acid Tyrosine, is a monoamine neurotransmitter that serves as a chemical messenger in the nervous system. It is the predominant Catecholamine neurotransmitter in the mammalian brain, where it controls functions such as locomotor activity, cognition, emotion, positive reinforcement, food intake, and endocrine regulation. Neurons in the midbrain release Dopamine, which modulates cAMP (Cyclic Adenosine 3 ,5 -Monophosphate) production by activating DRDs (Dopamine Receptors) (Ref.1). On the basis of their molecular structure and pharmacological [...]


1.Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMPproduction.
Franz D, Contreras F, González H, Prado C, Elgueta D, Figueroa C, Pacheco R.
J Neuroimmunol. 2015 Jul 15;284:18-29. doi: 10.1016/j.jneuroim.2015.05.003. Epub 2015 May 1.
2.Immunomodulatory Effects Mediated by Dopamine.
Arreola R, Alvarez-Herrera S, Pérez-Sánchez G, Becerril-Villanueva E, Cruz-Fuentes C, Flores-Gutierrez EO, Garcés-Alvarez ME, de la Cruz-Aguilera DL, Medina-Rivero E, Hurtado-Alvarado G, Quintero-Fabián S, Pavón L.
J Immunol Res. 2016;2016:3160486. Epub 2016 Oct 4. Review.
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