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Dopamine-DARPP32 Feedback onto cAMP Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


One of the ultimate frontiers for mankind is the elucidation of the function of the mind. Dopaminergic and Glutamergic are two primary neurotransmitter systems in the brain, which are crucially important for the control of the body musculature and the Dopamine-induced signaling pathways. Dopamine, a derivative of the amino acid Tyrosine, is a monoamine neurotransmitter that serves as a chemical messenger in the nervous system. It is the predominant Catecholamine neurotransmitter in the mammalian brain, where it controls functions such as locomotor activity, cognition, emotion, positive reinforcement, food intake, and endocrine regulation. Neurons in the midbrain release Dopamine, which modulates cAMP (Cyclic Adenosine 3 ,5 -Monophosphate) production by activating DRDs (Dopamine Receptors) (Ref.1). On the basis of their molecular structure and pharmacological [...]


1.Decoding dopamine signaling.
Bibb JA.
Cell. 2005 Jul 29;122(2):153-5.
2.The dopamine D2 receptor: new surprises from an old friend.
Bonci A, Hopf FW.
Neuron. 2005 Aug 4;47(3):335-8.
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