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Drosophila PI3K Pathway

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The PI3K (Phosphatidylinositde-3 Kinase) family of enzymes is recruited upon growth factor receptor activation and produces 3 phosphoinositide lipids. The lipid products of PI3K act as second messengers by binding to and activating diverse cellular target proteins. Therefore, PI3Ks play a central role in many cellular functions. In mammals, the PI3Ks have a p110 catalytic subunit associated with a p85, p55 or p50 regulatory subunit (Ref.1). In Drosophila, the dPI3K (Phosphatidylinositde-3 Kinase) regulatory subunit dp60 (p60 Regulatory Subunit of PI3K) lacks the SH3 and BH (Bcr homology) domains like that of the mammals showing that these additional domains have been added during evolution to confer additional functions or modes of regulation to the PI3K signaling pathways. The dPI3K along with [...]


1.Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.
Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD.
Annu. Rev. Cell Dev. Biol. 2001;17:615-75.
2.p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110.
Weinkove D, Leevers SJ, MacDougall LK, Waterfield MD.
J. Biol. Chem. 1997 Jun 6; 272(23): 14606-10.
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