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EGF Pathway

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Description

EGF (Epidermal Growth Factor) is a small 53 amino acid residue protein that is involved in normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and functional homology with hTGF-Alpha (human type-Alpha Transforming Growth Factor), which is a competitor for EGF receptor sites. EGF binds to a specific high-affinity, low-capacity receptor on the surface of responsive cells known as EGFR (Epidermal growth factor receptor). EGFR is a member of the ErbB (Erythroblastic Leukemia Viral Oncogene Homolog) family receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB1), Her2/c-neu (ErbB2), Her3 (ErbB3) and Her4 (ErbB4). In response to toxic environmental stimuli, such as ultraviolet irradiation, or to receptor occupation by EGF, the EGFR forms Homo- [...]

References:

1.EGFR-expression in pulmonary neuroendocrine cell hyperplasia.
Kuhnen C, Winter BU.
Pathologe. 2006 Mar;27(2):147-51.
2.Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts.
Smith KD, Wells A, Lauffenburger DA.
Exp Cell Res. 2006 Apr 2;
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