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EGF Pathway

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Angiogenesis, the growth of new blood vessels, plays a key role in many physiological and pathological processes, such as ovulation, embryogenesis, wound repair, inflammation, malignant tumor growth, retinopathies, rheumatoid arthritis, and angiogenesis-dependent diseases. One of the best-characterized modulators of angiogenesis is the heparin-binding FGF (Fibroblast Growth Factor) (Ref. 1).

FGFs are a large family of multifunctional peptide growth factors of which there are at least 28 distinct members. The members of this peptide growth factor family have been identified in a variety of organisms and play pivotal roles in many cellular processes including mitogenesis, differentiation, migration, and cell survival During embryonic development, FGFs play a critical role in morphogenesis by regulating cellular proliferation, differentiation, and migration.In the adult, FGFs are [...]


1.A review on angiogenesis and its assays.
Tahergorabi Z, Khazaei M.
Iran J Basic Med Sci. 2012 Nov;15(6):1110-26.
2.Fibroblast growth factor (FGF) signaling in development and skeletal diseases.
Teven CM, Farina EM, Rivas J, Reid RR.
Genes Dis. 2014 Dec 1;1(2):199-213.
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