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ER-Mediated Phagocytosis

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Phagocytosis, the process by which cells engulf foreign particles, occurs in eukaryotes ranging from unicellular organisms, which use it for nutrition, to mammals, where it plays a key role in innate immunity. The remarkable phagocytic capacity of Macrophages is illustrated by their ability to internalize particles that can be as large as themselves without impairing their function and viability. Although most of the models of Phagocytosis present the plasma membrane as the main source of membrane for phagosome formation, the observation that Macrophages can internalize particles as large as themselves raise questions about the source of membrane to carry out this process. Indeed, in these cases, the plasma membrane is not sufficient and other sources of membranes have to be [...]


1.Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages.
Gagnon E, Duclos S, Rondeau C, Chevet E, Cameron PH, Steele-Mortimer O, Paiement J, Bergeron JJ, Desjardins M.
Cell. 2002 Jul 12;110(1):119-31.
2.Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages.
Becker T, Volchuk A, Rothman JE.
Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4022-6.
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