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ERBB Family Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The ErbB (Erythroblastic Leukemia Viral Oncogene Homolog) or EGF (Epidermal Growth Factor) family of transmembrane RTKs (Receptor Tyrosine Kinases) plays an important role during the growth and development of a number of organs including the heart, the mammary gland, and the central nervous system. In addition, ErbB overexpression is associated with tumorigenesis of the breast, ovaries, brain, and prostate gland. The ErbB family includes four members, EGFR (EGF Receptor)/ErbB1/Her1 (Heregulin-1), ErbB2/Her2 (Heregulin-2), ErbB3/Her3 (Heregulin-3), and ErbB4/Her4 (Heregulin-4) (Ref.1). Two of the family members, ErbB1 and ErbB2, are involved in the development of many types of human cancer. All ErbBs have in common an extracellular ligand-binding domain, a single membrane-spanning region, and a cytoplasmic protein tyrosine kinase domain (Ref.2). Although these [...]


1.The ErbB receptor tyrosine family as signal integrators.
Hynes NE, Horsch K, Olayioye MA, Badache A.
Endocr Relat Cancer. 2001 Sep;8(3):151-9.
2.The ErbB receptors and their role in cancer progression.
Holbro T, Civenni G, Hynes NE.
Exp Cell Res. 2003 Mar 10;284(1):99-110.
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