ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

ERK Signaling

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

The MAPK (Mitogen-Activated Protein Kinase) pathway is one of the primordial signaling systems that nature has used in several permutations to accomplish an amazing variety of tasks. It exists in all eukaryotes, and controls such fundamental cellular processes as Proliferation, Differentiation, Survival and Apoptosis. Mammalian MAPK can be divided into four groups based on their structure and function: ERKs (Extracellular signal-Regulated Kinases), p38MAPKs, JNKs (c-Jun NH2-terminal Kinases) and ERK5 (Extracellular signal-Regulated Kinase-5) or BMK. Activation of these MAPKs occurs through a cascade of upstream kinases; a MAPKKK (MAPK Kinase Kinase) first phosphorylates a dual-specificity protein kinase MAPKK (MAPK Kinase), which in turn phosphorylates the MAPK. This set-up provides not only for signal amplification, but, maybe even more importantly, for additional regulatory interfaces [...]

References:

1.Mitogen-activated protein kinases in apoptosis regulation.
Wada T, Penninger JM.
Oncogene. 2004 Apr 12;23(16):2838-49.
2.Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death.
Subramaniam S, Unsicker K.
Neuroscience. 2006;138(4):1055-65. Epub 2006 Jan 25.
You can get all the details on this pathway through subscription