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ERK5 Signaling

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ERK5 (also known as the BMK1 (Big MAP Kinase-1)) is an atypical MAPK that can be activated in vivo by a variety of stimuli, including Serum, Growth factors including EGF (Epidermal Growth Factor), NGF (Nerve Growth Factor) and BDNF (Brain-Derived Neurotrophic Factor), GPCRs (G-Protein Coupled Receptors), Lysophosphatidic Acid, Neurotrophins and Phorbol ester and some Cellular stress such as Oxidative and Osmotic Shock. MAPK (Mitogen Activated Protein Kinase) cascades play important roles in many cellular processes including cell proliferation, differentiation, survival and apoptosis. They are also important for many physiological functions in several systems, including in developmental, immune and neuronal systems. At least 12 isoforms of MAPKs exist in mammalian cells, and these can be divided into 4 main groups, the [...]


1.Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate.
Liu L, Cundiff P, Abel G, Wang Y, Faigle R, Sakagami H, Xu M, Xia Z.
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9697-702. Epub 2006 Jun 9.
2.Investigating the cellular BMK1/ERK5 signaling pathway.
Tapping RI, Yutaka K, Chao TH, Hayashi M, Lo JF, Kim SW, Lee JD.
Methods Mol Biol. 2004;250:89-96.
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