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Embryonic Cell Differentiation into Cardiac Lineages

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Stem Cells are undifferentiated cells with broad developmental potential. They are able to generate various specialized cell types and, in addition, have the capacity to self-renew and thus to produce undifferentiated progeny that retain Stem Cell features. These properties allow Stem Cells to provide developing organs with appropriate numbers of differentiated cells and to control tissue maintenance, regeneration and repair. The Heart is the first functional organ formed during Embryonic development. Heart development is an elaborate process requiring cell specification, cell differentiation, cell migration, morphogenesis, and interactions among cells from several embryonic origins. It arises from paired regions of dorsolateral mesoderm that are specified by inductive interaction with adjacent tissues. In all vertebrates, the myogenic and endocardial lineages of the [...]


1.Development of the building plan of the heart.
Moorman AF, Soufan AT, Hagoort J, de Boer PA, Christoffels VM.
Ann N Y Acad Sci. 2004 May;1015:171-81.
2.Redundancy and evolution of GATA factor requirements in development of the myocardium.
Peterkin T, Gibson A, Patient R.
Dev Biol. 2007 Aug 16;
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