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Endocytic Trafficking of EGFR

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Description

All cells need to interpret their environment. Efficient processing of signals from the extracellular milieu is achieved through dynamic signal-transduction systems. The components of this system that come into contact first with external signals are cell-surface receptors. RTKs (Receptor Tyrosine Kinases) comprise one large group of receptors that respond to polypeptide growth factors and have intrinsic tyrosine kinase activity. On ligand binding, receptor signaling is activated. The activation of RTKs initiates signal transduction and receptor endocytosis. Most activated RTKs are efficiently cleared from the cell surface by endocytosis and sorted to Lysosomes for degradation. In contrast, inactive RTKs are constitutively internalized and recycled back to the cell surface, an essential mechanism for the restoration of unused receptors. Simultaneous signal transduction [...]

References:

1.Signal transduction and endocytosis: close encounters of many kinds.
Sorkin A, Von Zastrow M.
Nat Rev Mol Cell Biol. 2002 Aug;3(8):600-14.
2.Regulation of receptor tyrosine kinase signaling by endocytic trafficking.
Wiley HS, Burke PM.
Traffic. 2001 Jan;2(1):12-8.
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