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Endothelin-1 Signaling Pathway

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Description

Cardiac hypertrophy describes an abnormal condition where the heart becomes enlarged. Several factors, such as increased mechanical loading and neuro-hormonal chemicals can induce hypertrophy. ET1 (Endothelin-1) is a 21-amino acid vasoconstrictor peptide, which is able to induce cardiac hypertrophy. In mammals this peptide family also includes ET2 and ET3. ET1 is the principal isoform in the human cardiovascular system and remains the most ubiquitous, potent, and unusually long-lasting constrictor of human vessels discovered. Biosynthesis of ET1 is primarily regulated by autocrine mechanisms, physico-chemical factors, including mechanical forces, changes in oxygen tension, changes in pH, Angiotensin-II, Vasopressin, Norepinephrine, growth factors, cytokines, lipoproteins and adhesion molecules. Inhibitors of ET1 synthesis include NO (Nitric Oxide) and its intracellular effectors, cGMP (cyclic Guanosine Monophosphate), [...]

References:

1.Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways.
Cheng RY, Basudhar D, Ridnour LA, Heinecke JL, Kesarwala AH, Glynn S, Switzer CH, Ambs S, Miranda KM, Wink DA.
Nitric Oxide. 2014 Dec 1;43:17-28. doi: 10.1016/j.niox.2014.08.003. Epub 2014 Aug 19. Review.
2.Cell communications in the heart.
Tirziu D, Giordano FJ, Simons M.
Cell communications in the heart. Circulation. 2010 Aug 31;122(9):928-37. doi: 10.1161/CIRCULATIONAHA.108.847731. Review. No abstract available.
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