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Enteropathogenic E.coli Induced Diarrhea

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Pathogenic microbes subvert normal host-cell processes to create a specialized niche, which enhances their survival. A common and recurring target of pathogens is the host cell s cytoskeleton, which is utilized by these microbes for purposes that include attachment, entry into cells, movement within and between cells, vacuole formation and remodeling, and avoidance of phagocytosis. One such subversive microbe is a gram-negative pathogen EPEC (Enteropathogenic Escherichia coli) that causes chronic, watery diarrhea in humans, primarily young children and infants. Central to EPEC-mediated disease is its colonization of the intestinal epithelium. After initial adherence, EPEC causes the localized effacement of microvilli and intimately attaches to the host cell surface, forming characteristic A/E (attaching and effacing) lesions. A/E pathogens typically reside on a [...]


1.Exploitation of host cells by enteropathogenic Escherichia coli.
Vallance BA, Finlay BB.
Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):8799-806.
2.The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69.
Elliott SJ, Wainwright LA, McDaniel TK, Jarvis KG, Deng YK, Lai LC, McNamara BP, Donnenberg MS, Kaper JB.
Mol Microbiol. 1998 Apr; 28(1):1-4.
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