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EphB-EphrinB Signaling

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The Eph family forms the largest group of RTKs (Receptor Tyrosine Kinases) comprising 14 members in mammals that play critical roles in diverse biological processes during development as well as in the mature animal. They are activated by membrane-bound ligands called Ephrins, which are classified into two subclasses based on their mode of membrane anchorage. The Ephrin-A ligands are GPI (Glycosylphosphatidylinositol)-linked and prefer to bind to EphA Receptors. The Ephrin-B ligands (Ephrin-B1–B3), which possess a transmembrane moiety and a short cytoplasmic domain, bind to EphB Receptors (EphB1–B6). The interactions between Ephrins and Eph Receptors are generally promiscuous within each subclass (Ref.1). Upon stimulation by Ephrin ligands, Eph Receptors activate signaling cascades in various biological systems. Interactions between Ephs and Ephrins [...]


1.Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation.
Xu Z, Lai KO, Zhou HM, Lin SC, Ip NY
J Biol Chem. 2003 Jul 4; 278(27):24767-75. Epub 2003 Apr 22.
2.Control of cell behaviour by signalling through Eph receptors and ephrins.
Mellitzer G, Xu Q, Wilkinson DG.
Curr Opin Neurobiol. 2000 Jun; 10(3):400-8. Review.
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