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EphrinA-EphR Signaling

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Neuronal growth cones in the developing nervous system are guided to their targets by attractive and repulsive guidance molecules, which include members of the netrin, semaphorin, ephrin, and Slit protein families. The Eph family forms the largest group of RTKs (Receptor Tyrosine Kinases) comprising 14 members in mammals that play critical roles in diverse biological processes during development as well as in the mature animal. They are activated by membrane-bound ligands called Ephrins, which are classified into two subclasses based on their modes of membrane anchorage. The EphrinA ligands are tethered to the plasma membrane by GPI (Glycosylphosphatidylinositol) anchor and prefer to bind to EphA Receptors. The EphrinB ligands (EphrinB1–B3), which possess a transmembrane moiety and a short cytoplasmic domain, [...]


1.Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation.
Xu Z, Lai KO, Zhou HM, Lin SC, Ip NY.
J Biol Chem. 2003 Jul 4; 278(27):24767-75. Epub 2003 Apr 22.
2.Control of cell behaviour by signalling through Eph receptors and ephrins.
Mellitzer G, Xu Q, Wilkinson DG.
Curr Opin Neurobiol. 2000 Jun; 10(3):400-8. Review.
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