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Epithelial Adherens Junctions

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Description

Adhesion between neighboring epithelial cells is a crucial and tightly controlled process. The integrity of cell-cell contacts is essential for the regulation of electrolyte absorption and for the prevention of tumor metastasis. In polarized epithelia, specialized structures such as Adherens Junctions (AJs) and Tight Junctions (TJs) are responsible for the establishment of contacts between neighboring cells. The establishment and stability of Adherens Junction is tightly regulated-in particular, by Growth Factors, cytokines and hormones. Such regulation, although poorly understood, is quite essential for the modulation of paracellular permeability in various epithelia, for the epithelium mesenchyme transition, and for development, morphogenesis and wound healing (Ref.1). The Adherens Junctions in epithelial cells are specialized structures for the cell-cell adhesion machinery and consist of [...]

References:

1.Phosphatase regulation of intercellular junctions.
McCole DF.
Tissue Barriers. 2013 Dec 1;1(5):e26713. doi: 10.4161/tisb.26713. Epub 2013 Oct 10. Review.
2.Cadherin controls nectin recruitment into adherens junctions by remodeling the actin cytoskeleton.
Troyanovsky RB, Indra I, Chen CS, Hong S, Troyanovsky SM.
J Cell Sci. 2015 Jan 1;128(1):140-9. doi: 10.1242/jcs.161588. Epub 2014 Nov 13.
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