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ErbB2-ErbB3 Heterodimers

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The ErbB (Erythroblastic Leukemia Viral Oncogene Homolog) family of transmembrane RTKs (Receptor Tyrosine Kinases) plays an important role in the pathogenesis of many cancers (Ref.1). This family is comprised of four members EGFR (Epidermal Growth Factor Receptor), ErbB2, ErbB3, and ErbB4 (Ref.2). ErbB2 also called Her2 (Heregulin-2) and ErbB3 are closely related to the EGFR/ErbB1, but unlike EGFR, ErbB2 is a ligandless receptor, whereas ErbB3 lacks tyrosine kinase activity. Hence, both ErbB2 and ErbB3 are active only in the context of ErbB heterodimers, and ErbB2-ErbB3 heterodimers, which are driven by Nrg (Neuregulin) ligands, are the most prevalent and potent complexes in terms of cell growth and transformation. The basis for the potency of signaling by the ligand-activated ErbB2-ErbB3 heterodimer lies [...]


1.Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2.
Nagy P, Vereb G, Sebestyen Z, Horvath G, Lockett SJ, Damjanovich S, Park JW, Jovin TM, Szollosi J.
J Cell Sci. 2002 Nov 15;115(Pt 22):4251-62.
2.ErbB2 is required for muscle spindle and myoblast cell survival.
Andrechek ER, Hardy WR, Girgis-Gabardo AA, Perry RL, Butler R, Graham FL, Kahn RC, Rudnicki MA, Muller WJ.
Mol Cell Biol. 2002 Jul;22(13):4714-22.
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