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Erythrocyte Invasion by Plasmodium Merozoite

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Human Malaria is caused by infection with four species of the intracellular parasitic protozoan genus Plasmodium that are transmitted by Anopheles mosquitoes. Of these four species, Plasmodium falciparum is the most lethal. At present, at least 300 million people are affected by Malaria globally and accounts for 0.7-2.7 million annual deaths. The life cycle of the Malarial parasite requires specialized protein expression for life in mammals and insects, intracellular and extracellular environments, and evasion of host immune response. Life cycle of Plasmodium inside human body can be broadly classified into 2 phases: Pre/ Exo-erythrocytic phase, and Erythrocytic phase. The Asexual Erythrocytic phase in the life cycle of Malarial parasites produces the clinical symptoms and pathology associated with infection. The Erythrocytic [...]


1.Motile systems in malaria merozoites: how is the red blood cell invaded?
Pinder J, Fowler R, Bannister L, Dluzewski A, Mitchell GH.
Parasitol Today. 2000 Jun;16(6):240-5. Review.
2.Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development.
Bannister LH, Hopkins JM, Dluzewski AR, Margos G, Williams IT, Blackman MJ, Kocken CH, Thomas AW, Mitchell GH.
J Cell Sci. 2003 Sep 15;116(Pt 18):3825-34. Epub 2003 Aug 05.
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