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Erythropoietin Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Erythropoiesis is a major pathway for Erythrocyte production, by which pluripotent Hematopoietic Stem Cells give rise to mature end stage cells via a series of differentiations. Epo (Erythropoietin), a glycoprotein hormone and a multifunctional Hematopoietic Cytokine ligand, is the master regulator of Erythropoiesis. As a major function, it monitors the safe passage of the committed Erythroid progenitor cells through several physiological and developmental stages by stimulating Growth, preventing Apoptosis, and promoting terminal differentiation. In addition to its immense survival strategies, Epo initiates Hemoglobin synthesis and is an essential viability and Growth factor in the maintenance of a steady physiological level of circulating Erythrocyte mass which ensure adequate tissue Oxygen levels and maintain an appropriate Oxygen supply throughout the body (Ref.1 & 2). It is [...]

References:

1.Erythropoietin regulations in humans under different environmental and experimental conditions.
Gunga HC, Kirsch KA, Roecker L, Kohlberg E, Tiedemann J, Steinach M, Schobersberger W.
Respir Physiol Neurobiol. 2007 Mar 12
2.PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors.
Schmidt EK, Fichelson S, Feller SM.
BMC Biol. 2004 May 18;2:7.
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