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Exo-Erythrocytic Phase of Malaria Parasite

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Malaria (from the Italian mal aria, meaning bad air) is an Acute infection caused by four species of the Protozoa genus Plasmodium: P.falciprium, P.vivax, P.malariae and P.ovale. Plasmodium falciparum is the main cause of disease and death from Malaria. The parasite is transmitted to Humans through the bite of the infected female Anopheles Mosquito. Life cycle of Plasmodium inside Human body can be broadly classified into 2 phases: Pre/ Exo-Erythrocytic phase, and Erythrocytic phase. Exo-Erythrocytic cycle begins when the carrier Female Anopheles mosquito takes a blood meal. Mosquito injects Sporozoites into Human body during the blood meal. Sporozoites travel to the liver to initiate the infection (Ref.1). The entry of Sporozoites to Hepatocytes is mediated through a specific Receptor-ligand interaction. Sporozoite [...]


Maitland K, Molyneux M.
Adv Exp Med Biol. 2004;549:125-34.
2.The Plasmodium sporozoite journey: a rite of passage.
Kappe SH, Kaiser K, Matuschewski K.
Trends Parasitol. 2003 Mar;19(3):135-43. Review.
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