About Us
Contact Us
Login to Protein Lounge!

Extrinsic Prothrombin Activation Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Thrombin/TFIIa (Activated Factor-II) is a coagulation protein that has many effects in the Coagulation cascade, the homeostatic process of greatest interest. It is a multifunctional serine proteinase best known for its ability to cleave Fibrinogen to Fibrin. Fibrin forms an essential component of the Blood Clot. When a blood vessel is injured, bleeding is stopped by clotting factors which form a Thrombus/Clot of Fibrin threads that trap platelet aggregates. A clot is a jelly-like mass of thickened blood composed of Fibrin and platelet aggregates. The first step in clotting is adhesion of platelets, which are fragments of blood cells that circulate in the blood, to the cut edges of a damaged blood vessel. In this way, a platelet plug is [...]


1.A cell-based model of thrombin generation.
Roberts HR, Hoffman M, Monroe DM.
Semin Thromb Hemost. 2006 Apr;32 Suppl 1:32-8.
2.Rethinking the coagulation cascade.
Hoffman MM, Monroe DM.
Curr Hematol Rep. 2005 Sep;4(5):391-6.
You can get all the details on this pathway through subscription