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FAK1 Signaling

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Description

Engagement of integrin receptors with extracellular ligands gives rise to the formation of complex multi-protein structures that link the ECM (Extracellular Matrix) to the cytoplasmic actin cytoskeleton and signaling proteins including Talin, Alpha-actinin, Vinculin, Zyxin, Paxillin and FAK (Focal Adhesion Kinase). These adhesive complexes are dynamic, often heterogeneous structures, varying in size and organization, and signaling through these complexes and focal adhesions have been implicated in the regulation of a number of key cellular processes, including growth factor induced mitogenic signals, cell survival, cell proliferation and migration, cell locomotion and regulation of cell cycle (Ref.1). FAK is a non-receptor cytosolic PTK with a central catalytic domain flanked by large N- and C-terminal domains that indirectly localizes to sites of integrin-receptor [...]

References:

1.Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation.
Sawai H, Okada Y, Funahashi H, Matsuo Y, Takahashi H, Takeyama H, Manabe T.
Mol Cancer. 2005 Oct 6; 4:37
2.Amplification and oscillations in the FAK/Src kinase system during integrin signaling
Caron-Lormier G, Berry H.
J Theor Biol. 2005 Jan 21;232(2):235-48.
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