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Fas Signaling

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Description

Fas (also called Apo1 or CD95) is a death domain-containing member of the TNFR (Tumor Necrosis Factor Receptor) superfamily. It has a central role in the physiological regulation of Programmed Cell Death and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. Although the FasL (Fas Ligand)-Fas system has been appreciated mainly with respect to its death-inducing function, it also transduces proliferative and activating signals through pathways that are still poorly defined. The Fas Receptor induces an apoptotic signal by binding to FasL expressed on the surface of other cells. Fas is a Type-I transmembrane protein, where as FasL a Type-II Transmembrane protein of TNF family and can be shed in a soluble form [...]

References:

1.Hepatocyte death: a clear and present danger.
Malhi H, Guicciardi ME, Gores GJ.
Physiol Rev. 2010 Jul;90(3):1165-94.
2.Cellular stress responses: cell survival and cell death.
Fulda S, Gorman AM, Hori O, Samali A.
Int J Cell Biol. 2010;2010:214074. Epub 2010 Feb 21.
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