About Us
Contact Us
Login to Protein Lounge!

Fc-EpsilonRI Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The formation of antigen-antibody complexes plays a fundamental role in our immune defense system. Interaction of these complexes with many cells of the immune system results in a variety of critical functions, including phagocytosis, antibody-dependent cytotoxicity, modulation of antibody secretion, cell secretion and sometimes the secretion and generation of an array of mediators that induce allergic inflammations (Ref.1). Receptors involved in antigen recognition by cells of the immune system include BCRs (B-Cell Receptors), TCRs (T-Cell Receptors), and the FcRs (Fc Receptors) that bind to their corresponding Igs (Immunoglobulins) through Fc domains. FcRs exist for every antibody class: Fc-GammaRs bind IgG, Fc-AlphaRs bind IgA, FcEpsilonRs bind IgE, FcMuRs bind IgM and FcDeltaRs bind IgD (Ref.2). The multisubunit high-affinity IgE receptor, FcEpsilonRI (FcEpsilonReceptorI) expressed [...]


1.The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology.
Kinet JP.
Annu Rev Immunol. 1999;17:931-72. Review.
2.Fc receptor biology.
Daeron M.
Annu Rev Immunol. 1997;15:203-34. Review.
You can get all the details on this pathway through subscription