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Fc-EpsilonRI Pathway

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Description

FcεRI is constitutively expressed on mast cells as a tetrameric receptor composed of the IgE-binding α chain, the membrane-tetraspanning β chain, and the disulfide-linked homodimer of the γ chains. The level of expression of the FcεRI on the mast cell surface can be influenced by several factors, such as IgE availability or IgE binding. Antigen (Ag) ligation of IgE-bound FcεRI initiates phosphorylation cascades that cause profound morphological and transcriptional modifications. As FcεRI lacks intrinsic tyrosine kinase activity, its activation requires the downstream phosphorylation of several Src kinases (LYN, SYK, and FYN) (Ref.1).Allergic rhinitis, asthma, atopic dermatitis, and food and drug allergies, which in some cases can lead to life-threatening anaphylaxis, are the result of IgE-mediated allergic reactions, the pathophysiology of [...]

References:

1.Mast cell activation: a complex interplay of positive and negative signaling pathways.
Sibilano R, Frossi B, Pucillo CE.
Eur J Immunol. 2014 Sep; 44(9):2558-66.
2.New developments in FcepsilonRI regulation, function and inhibition.
Kraft S, Kinet JP.
Nat Rev Immunol. 2007 May; 7(5):365-78.
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