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Fc-Gamma-RIIB Signaling in B-Cells

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The ability of the immune system to respond appropriately to foreign antigen is dependent on a delicate balance of activating and inhibitory signals. Although positive signaling is essential for the generation of effective immunity, counterbalancing the immune response by inhibitory pathways is equally important. Loss of inhibitory signaling is often associated with autoreactivity and unchecked inflammatory responses, illustrating the essential role these systems play in immune regulation (Ref.1). Pairing of activation and inhibition is therefore, necessary to modulate immune responses. The activation threshold of various cells in the immune system is tuned by immune inhibitory receptors. The inhibitory Fc (Crystalline Fragment) Receptor, Fc-Gamma-RIIB (Fc-Gamma Receptor-IIB), is one of the critical molecules for the regulation of immune responses through antibodies (Ref.2). [...]


1.IgG Fc receptors.
Ravetch JV, Bolland S.
Annu Rev Immunol. 2001;19:275-90.
2.Fc receptors as potential targets for the treatment of allergy, autoimmune disease and cancer.
Takai T, Nakamura A, Akiyama K.
Curr Drug Targets Immune Endocr Metabol Disord. 2003 Sep;3(3):187-97.
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