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G-AlphaI Signaling

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The heterotrimeric G-Proteins (Guanine nucleotide-binding Proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions, known as GPCR (G-Protein Coupled Receptor), that activate the G-proteins, which route the signals to several distinct intracellular signaling pathways. These pathways interact with one another to form a network that regulates metabolic enzymes, ion channels, transporters, and other components of the cellular machinery controlling a broad range of cellular processes, including transcription, motility, contractility, and secretion. These cellular processes in turn regulate systemic functions such as embryonic development, gonadal development, learning and memory, and organismal homeostasis. Heterotrimeric G-proteins are composed [...]


1.Mammalian G proteins and their cell type specific functions.
Wettschureck N, Offermanns S.
Physiol Rev. 2005 Oct;85(4):1159-204.
2.Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.
Pabst O, Herbrand H, Willenzon S, Worbs T, Schippers A, Muller W, Bernhardt G, Forster R.
J Immunol. 2006 Feb 1;176(3):1474-80.
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