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Description |
Cell cycle arrest in response to DNA damage is an important mechanism for
maintaining genomic integrity. This cell cycle arrest provides time for DNA
repair to prevent replication or segregation of damaged DNA. Induction of growth
arrest by DNA damage occurs mainly through the activation of checkpoint pathways
that delay cell cycle progression at G1, S, and G2 (Ref.1).
In vertebrate
cells, the commitment to complete a round of mitotic division takes place during
the initial phase of the cell cycle (G1), at a stage called the restriction (R)
point, preceding the onset of DNA synthesis (S-phase) (Ref.2). Two cell cycle
kinases, CDK4/6 (Cyclin-Dependent Kinase)-Cyclin-D and CDK2-Cyclin-E, and the
transcription complex that includes Rb (Retinoblastoma)-family proteins (also
called "pocket proteins") and [...] |
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References:
1. DNA double-strand breaks: signaling, repair and the cancer connectionKhanna KK, Jackson SPNat Genet. 2001 Mar; 27(3): 247-54. Review2. What is the restriction point?Zetterberg A, Larsson O, Wiman KGCurr Opin Cell Biol. 1995 Dec; 7(6): 835-42. Review
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