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G12-G13 in Cellular Signaling

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The G12 subfamily of heterotrimeric G proteins, comprised of the Alpha-subunits G-Alpha12 and G-Alpha13, has been implicated as a signaling component in cellular processes ranging from cytoskeletal changes to cell growth and oncogenesis. Activated G-Alpha12 and G-Alpha13 have a molecular weight of 43,000 kDa and they show more than 66% amino acid identity. They stimulate mitogenic signaling pathways leading to the oncogenic transformation of fibroblast cell lines. Recent analyses have indicated that G-Alpha12 and G-Alpha13 regulate cytoplasmic as well as nuclear signaling events through downstream targets such as Ras-, Rac-, Rho-, and CDC42 (Cell Division Cycle-42) dependent pathways, leading to cytoskeletal reorganization and to the activation of MAPK (Mitogen-Activated Protein Kinase), JNK (Jun N-terminal kinase), the Na+-H+(sodium/hydrogen) exchanger, c-Fos, SRE (Serum Response [...]


1.Signaling by the G12 class of G proteins.
Dhanasekaran N, Dermott JM.
Cell Signal 1996 Jun;8(4):235-45.
2.Identification of a prostate-specific G-protein coupled receptor in prostate cancer.
Xia C, Ma W, Wang F, Hua Sb, Liu M.
Oncogene. 2001 Sep 13;20(41):5903-7.
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