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G2-M Phase Transition

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The cellular responses to DNA damage induced by ionizing radiation include activation of cell cycle checkpoints that delay progression of cells through the cell cycle. Ionizing radiation-induced checkpoints are active at the transition from the G1-phase to the S-phase, in the S-phase, and at the transition from the G2-phase to mitosis (G2/M). The surveillance mechanisms responsible for initiating these checkpoints appear to facilitate maintenance of the integrity of the genome, presumably because they ensure that damaged DNA templates are neither replicated nor segregated into the daughter cells until they are repaired. The option to undergo apoptosis can be considered as one of the checkpoint endpoints, and a failure of the cell to die under appropriate circumstances can lead to inappropriate [...]


1.Two molecularly distinct G (2)/M checkpoints are induced by ionizing irradiation
Xu B, Kim ST, Lim DS, Kastan MB
Mol Cell Biol. 2002 Feb; 22(4): 1049-59
2.Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham RT
Genes Dev. 2001 Sep 1; 15(17): 2177-96. Review. No abstract available
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