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GADD45 Pathway

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Genotoxic stress is an important and ubiquitous type of stress that cells are inevitably exposed to over the life span of an organism. Many potentially damaging agents both from the environment and from endogenous processes involving activated oxygen species and other reactive agents can damage the DNA in cells (Ref.1). A major factor in the cellular response to DNA damage and other types of stress, including nucleotide pool depletion and hypoxia, is the p53 tumor suppresser gene, which is activated by ATM/ATR kinases. Upon detection of DNA damage the p53 protein, which functions as a transcription factor, is stabilized, and its elevated level results in induction of p53 target genes. GADD45 (Growth Arrest and DNA Damage-inducible) is one of several [...]


1.Regulation of Gadd45gamma expression by C/EBP.
Jung N, Yi YW, Kim D, Shong M, Hong SS, Lee HS, Bae I.
Eur J Biochem. 2000 Oct; 267(20): 6180-7.
2.Stress-induced JNK activation is independent of Gadd45 induction.
Shaulian E, Karin M.
J Biol Chem. 1999 Oct 15; 274(42): 29595-8.
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