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GSK3 Signaling

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Description

GSK3 (Glycogen Synthase Kinase-3) is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes. Identified originally as a regulator of glycogen metabolism, GSK3 acts as a downstream regulatory switch for numerous signaling pathways, including cellular responses to WNT, Growth Factors, Insulin, RTK (Receptor Tyrosine Kinases), Hedgehog pathways, and GPCR (G-Protein-Coupled Receptors) and is involved in a wide range of signal transduction cascades involving cellular processes, ranging from glycogen metabolism, cell development, gene transcription, protein translation to cytoskeletal organization, cell cycle regulation, proliferation and apoptosis. Unlike most protein kinases involved in signaling, GSK3 is active in unstimulated, resting cells and its activity is diminished during cellular responses. Another peculiarity compared with other protein kinases is its preference for [...]

References:

1.The Role of GSK3 in Presynaptic Function.
Smillie KJ, Cousin MA.
Int J Alzheimers Dis. 2011 Mar 14;2011:263673.
2.Deconstructing GSK-3: The Fine Regulation of Its Activity.
Medina M, Wandosell F.
Int J Alzheimers Dis. 2011;2011:479249. Epub 2011 Apr 28.
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