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Glioblastoma Multiforme

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Glioblastoma Multiforme (GBM) is biologically aggressive neoplasms which have an elevated, often aberrant, proliferative capacity with a diffuse pattern of brain invasion. It is the most malignant Astrocytic tumor, composed of poorly differentiated neoplastic astrocytes (Ref.1). The World Health Organization (WHO) grading system classifies Gliomas into Grades I-IV based on the degree of malignancy, as determined by histopathological criteria. In the Central Nervous System (CNS), Grade-I Gliomas generally behave in a benign fashion and might even be circumscribed, whereas Grade-II, Grade-III and Grade-IV Gliomas are malignant and diffusely infiltrate throughout the brain. Glioblastoma Multiforme falls under the Grade-IV category. Glioblastoma Multiforme or the WHO Grade-IV Astrocytoma is divided into two subtypes based on clinical characteristics: Primary and Secondary GBM. Primary [...]


1.Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.
Amos S, Martin PM, Polar GA, Parsons SJ, Hussaini IM.
J. Biol. Chem. 2005 Mar 4;280(9):7729-38.
2.Molecular changes in gliomas.
Sanson M, Thillet J, Hoang-Xuan K.
Curr. Opin. Oncol. 2004 Nov;16(6):607-13.
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