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Glioma Invasiveness

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Gliomas are the most common intracranial malignant tumors in humans, and high-grade Gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion (Ref.1). The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of Gliomas and contributes to the failure of current therapeutic modalities (surgery, radiation and chemotherapy). Transformed glial cells share the common attributes of the invasion process, including cell adhesion to ECM (Extracellular Matrix) components, cell locomotion, and the ability to remodel extracellular space. However, Glioma cells have the ability to invade as single cells through the unique environment of the normal CNS (Central Nervous System). The brain parenchyma has a unique composition, mainly Hyaluronan and is devoid of [...]


1.Molecular biology of glioma tumorigenesis.
Ware ML, Berger MS, Binder DK.
Histol. Histopathol. 2003 Jan;18(1):207-16.
2.Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion.
Bellail AC, Hunter SB, Brat DJ, Tan C, Van Meir EG.
Int. J. Biochem. Cell Biol. 2004 Jun;36(6):1046-69.
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