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Glucocorticoid Receptor Signaling

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Our bones get more brittle with increasing age, and to add insult to injury, the most effective therapy for another problem that is associated with getting older, rheumatoid arthritis, often adds to the problem by causing bone resorption. The Glucocorticoid steroids, are the best available anti-inflammatories, and are used widely in the treatment of arthritis, as well as other inflammatory conditions such as dermatitis and autoimmune diseases. The Glucocorticoids, secreted by the Adrenal Cortex are powerful anti-inflammatory compounds due to their ability to inhibit all stages of the inflammatory response, from redness to wound healing to cell proliferation (Ref.1). They are powerful anti-inflammatory compounds that have the ability to inhibit all stages of the inflammatory response. They also have an [...]


1.Glucocorticoid receptor signaling in health and disease.
Kadmiel M, Cidlowski JA.
Trends Pharmacol Sci. 2013 Sep;34(9):518-30. doi: 10.1016/ Epub 2013 Aug 14. Review.
2.The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease.
Oakley RH, Cidlowski JA.
J Allergy Clin Immunol. 2013 Nov;132(5):1033-44. doi: 10.1016/j.jaci.2013.09.007. Epub 2013 Sep 29. Review.
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