ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Glutathione Metabolism in A. gossypii

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. Furthermore, the Cysteine molecule has a sulfur-containing portion which gives the whole Glutathione molecule its ‘biochemical activity’. Cysteine can also enter the Glutathione metabolism through several other metabolic pathways like Cysteine, Taurine and Hypotaurine metabolism. Glutathione is homeostatically [...]

References:

1.Ashbya gossypii: a model for fungal developmental biology.
Wendland J, Walther A.
Nat Rev Microbiol. 2005 May; 3(5):421-9.
2.The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.
Dietrich FS, Voegeli S, Brachat S, Lerch A, Gates K, Steiner S, Mohr C, Pohlmann R, Luedi P, Choi S, Wing RA, Flavier A, Gaffney TD, Philippsen P.
Science. 2004 Apr 9; 304(5668):304-7.
You can get all the details on this pathway through subscription