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Glutathione Metabolism in Acinetobacter sp. ADP1

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Gram-negative bacteria of the genus Acinetobacter are classified in the gamma subdivision of the Gram-negative proteobacteria and more precisely on the Moraxellaceae branch. Isolates of Acinetobacter are characterized as strictly aerobic non-motile heterotrophic mesophiles, capable of utilising a great variety of substrates as carbon sources, from alkanes to organic acids, especially aromatic ones. The Acinetobacter sp. strain ADP1 is a nutritionally versatile soil bacterium, closely related to representatives of the well-characterized Pseudomonas aeruginosa and Pseudomonas putida (Ref.1).

Glutathione in Acinetobacter sp. is a tripeptide, composed of glutamate, cysteine and glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in the highest concentration in all types of cells. During Glutathione metabolism, the laevorotatory [...]


1.Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium.
Barbe V, Vallenet D, Fonknechten N, Kreimeyer A, Oztas S, Labarre L, Cruveiller S, Robert C, Duprat S, Wincker P, Ornston LN, Weissenbach J, Marliere P, Cohen GN, Medigue C.
Nucleic Acids Res. 2004 Oct 28; 32(19):5766-79.
2.A mutant Bacillus subtilis gamma-glutamyltranspeptidase specialized in hydrolysis activity.
Minami H, Suzuki H, Kumagai H.
FEMS Microbiol Lett. 2003 Jul 29; 224(2):169-73.
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