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Glutathione Metabolism in Azoarcus sp. EbN1

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Azoarcus sp. is associated with microbial degradation of aromatic and other refractory compounds, including hydrocarbons in anoxic waters and soils. Strain EbN1 is an aromatic-degrading bacteria found in freshwater and soil habitats. A unique property of strain EbN1 is its capacity to degrade toluene and ethylbenzene via two different, strictly anaerobic pathways. The absence of nitrogen fixation and specific interaction with plants separates EbN1 ecophysiologically from the closely related nitrogen-fixing plant symbionts of the Azoarcus cluster (Ref.1 & 2). Glutathione is an important water-phase antioxidant in Azoarcus sp. and essential cofactor for antioxidant enzymes. Glutathione is homeostatically controlled, both inside the cell and outside. Enzyme systems synthesize it, utilize it, and regenerate it as per the Gamma-Glutamyl Cycle. Glutathione exists [...]


1.The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1.
Rabus R, Kube M, Heider J, Beck A, Heitmann K, Widdel F, Reinhardt R.
Arch Microbiol. 2005 Jan; 183(1):27-36
2.Genes involved in the anaerobic degradation of toluene in a denitrifying bacterium, strain EbN1.
Kube M, Heider J, Amann J, Hufnagel P, Kuhner S, Beck A, Reinhardt R, Rabus R.
Arch Microbiol. 2004 Mar; 181(3):182-94.
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