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Glutathione Metabolism in B. bacteriovorus

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Bdellovibrio bacteriovorus is a tiny and highly motile Delta-Proteobacterium that preys on other Gram-negative bacteria. B. bacteriovorus attaches itself to the cell wall of its prey and invades the cell where it goes through a full-life cycle. After it reproduces, the offspring burst out of the cell. Despite its small size, it has a relatively large genome encoding more than 3500 proteins (Ref.1). Glutathione metabolism in B. bacteriovorus occurs within cells in two closely linked, enzymatically controlled reactions that utilize ATP and draw on nonessential amino acids as substrates. Glutathione is a tripeptide, composed of glutamate, cysteine and glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in the highest concentration [...]


1.A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective.
Rendulic S, Jagtap P, Rosinus A, Eppinger M, Baar C, Lanz C, Keller H, Lambert C, Evans KJ, Goesmann A, Meyer F, Sockett RE, Schuster SC.
Science. 2004 Jan 30; 303 (5658):689-92.
2.Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer.
Chu FF, Esworthy RS, Doroshow JH.
Free Radic Biol Med. 2004 Jun 15; 36(12):1481-95.
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