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Glutathione Metabolism in B. bronchiseptica

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Bordetella bronchiseptica, Bordetella pertussis and Bordetella parapertussis and are closely related Gram-negative Beta-proteobacteria that colonize the respiratory tracts of mammals. B. bronchiseptica causes chronic respiratory infections in a wide range of animals. B. bronchiseptica is encountered as a commensal or colonizer of the respiratory tract of humans and rarely in association with infection. When found as a probable pathogen, most infections have been respiratory tract in origin and have occurred in severely compromised hosts. The outer-membrane protein pertactin of B. bronchiseptica is believed to function as an adhesin and is an important immunogen (Ref.1 & 2).

Glutathione in Bordetella is a tripeptide, composed of Glutamate, Cysteine and Glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically [...]


1.Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
Parkhill J
Nat Genet. 2003 Sep; 35(1):32-40. Epub 2003 Aug 10.
2.PFGE and pertactin gene sequencing suggest limited genetic variability within the Finnish Bordetella parapertussis population.
Makinen J, Mertsola J, Soini H, Arvilommi H, Viljanen MK, Guiso N, He Q.
J Med Microbiol. 2003 Dec; 52(Pt 12):1059-63.
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