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Glutathione Metabolism in B. henselae

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Bartonella henselae is a fastidious, Gram-negative bacterial pathogen of cats and humans. Bartonella sp. are transmitted by insect vectors, using mammalian reservoirs, infecting similar cell types (Endothelial cells and Erythrocytes) and causing vasculoproliferative changes in immunocompromised hosts. B. henselae causes CSD (Cat Scratch Disease). Most people with CSD have been bitten or scratched by a cat and developed a mild infection at the point of injury. Lymph nodes, especially those around the head, neck, and upper limbs, become swollen. Additionally, a person with CSD may experience fever, headache, fatigue, and a poor appetite. Rare complications of B. henselae infection are bacillary angiomatosis and Parinaud s oculolandular syndrome (Ref.1 & 2). Glutathione is a small molecule found in Bartonella cell. Glutathione metabolism [...]


1.The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae.
Alsmark CM, Frank AC, Karlberg EO, Legault BA, Ardell DH, Canback B, Eriksson AS, Naslund AK, Handley SA, Huvet M, La Scola B, Holmberg M, Andersson SG.
Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9716-21
2.Phase variation in Bartonella henselae.
Kyme P, Dillon B, Iredell J.
Microbiology. 2003 Mar; 149(Pt 3):621-9
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