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Glutathione Metabolism in B. mallei

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Burkholderia mallei are gram negative bacteria and are evolved as obligate parasite of horses, mules, and donkeys with no other known natural reservoir. B.mallei is regarded as a potential biological weapon because it is highly infectious as an aerosol and results in a disease that is painful, incapacitating, difficult to diagnose, and often fatal (Ref.1 & 2). Glutathione is a tripeptide present in B. mallei sp., which is composed of Glutamate, Cysteine and Glycine, and has numerous important functions within cells. The tripeptide is the thiol compound, present in the highest concentration in all types of cells.

Glutathione metabolism in B. mallei involves both the synthesis of Glutathione and its catabolism. Glutathione biosynthesis starts from an L-Amino acid, which in presence [...]


1.Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice.
Ulrich RL, Amemiya K, Waag DM, Roy CJ, DeShazer D.
Vaccine 2005 Mar 14; 23(16):1986-92.
2.Antigenic relatedness between Burkholderia pseudomallei and Burkholderia mallei.
Anuntagool N, Sirisinha S.
Microbiol Immunol. 2002; 46(3):143-50.
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