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Description |
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Brucella is a Gram-negative aerobic pathogen that is distringuished
from most other pathogens because it does not have "obvious virulence factors"
like capsules, fimbriae, flagella, exotoxins, exproteases, or other exoenzymes,
cytolysins, resistance forms, antigenic variation, plamids, or lysogenic phages
(Ref.1). Brucella sp. causes a "zoonotic disease endemic in many areas
of the world, characterized by chronic infections in animals leading to abortion
and infertility, and a systemic, febrile illness in humans". Brucella
melitensis is the cause of brucellosis in goats, cattle, sheep, pigs, dogs,
marine mammals, and several wild animals. Goats are the natural hosts for B.
melitensis. This bacterium is also the cause of a rarer, more severe
systemic infection called neurobrucellosis. Most features related to virulence
seem to [...] |
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References:
1. The genome sequence of the facultative intracellular pathogen Brucella melitensis.DelVecchio VG, Kapatral V, Redkar RJ, Patra G, Mujer C, Los T, Ivanova N, Anderson I, Bhattacharyya A, Lykidis A, Reznik G, Jablonski L, Larsen N, D'Souza M, Bernal A, Mazur M, Goltsman E, Selkov E, Elzer PH, Hagius S, O'Callaghan D, Letesson JJ, Haselkorn R, Kyrpides N, Overbeek R.:Proc Natl Acad Sci U S A. 2002 Jan 8; 99(1):443-8.2. Indirect enzyme-linked immunosorbent assay for detection of Brucella melitensis-specific antibodies in goat milk.Funk ND, Tabatabai LB, Elzer PH, Hagius SD, Martin BM, Hoffman LJ.J Clin Microbiol. 2005 Feb; 43(2):721-5.
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