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Glutathione Metabolism in B. parapertussis

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Description

Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative Beta-proteobacteria that colonizes the respiratory tracts of mammals. B. parapertussis causes whooping cough in a wide range of animals. It produces a complex array of adhesins, aggressins and toxins that are presumed to be important in the colonisation of its human host and in ensuring its survival and propagation. Adherence of B. parapertussis to ciliated epithelia is species-specific making it unlikely that the transfer of B. parapertussis between humans and sheep will result in an infection (Ref.1 & 2).

Glutathione in Bordetella is a tripeptide, composed of Glutamate, Cysteine and Glycine, and has numerous important [...]

References:

1.Ultrastructural analysis of the interactions between Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica and human tracheal epithelial cells.
Gueirard P, Bassinet L, Bonne I, Prevost MC, Guiso N.
Microb Pathog. 2005 Jan; 38(1):41-6.
2.Whooping cough due to Bordetella parapertussis: an unresolved problem.
Watanabe M, Nagai M.
Expert Rev Anti Infect Ther. 2004 Jun; 2(3):447-54.
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